Quantitive systematic review of topically applied non-steroidal anti-inflammatory drugs

Quantitative systematic review of topically applied non-steroidal anti-inflammatory drugs.

OBJECTIVE To review the effectiveness and safety of topical non-steroidal anti-inflammatory drugs in acute and chronic pain conditions. DESIGN Quantitative systematic review of randomised controlled trials. DATA SOURCES 86 trials involving 10,160 patients. MAIN OUTCOME MEASURES Measures of treatment success approximating at least 50% reduction in pain, local and systemic adverse effects. ...

Systematic review: the hepatotoxicity of non-steroidal anti-inflammatory drugs.

BACKGROUND Non-steroidal anti-inflammatory drugs have been implicated in reports of liver injury. However, the precise risk of non-steroidal anti-inflammatory drugs for this rare complication is unknown. AIM To review systematically the published literature of population-based epidemiological studies reporting the incidence or comparative risk of non-steroidal anti-inflammatory drugs for live...

Non-steroidal anti-inflammatory drugs.

Safety of non-steroidal anti-inflammatory drugs.

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in medical practice for treating pain, inflammation and degenerative joint diseases (for instance, arthritis). The use of traditional NSAIDs (tNSAIDs), however, is associated with an increased risk of minor and serious gastrointestinal (GI) events. It is estimated that in the European Union thousands of gastrointestinal complication...

Non-steroidal anti-inflammatory drugs inhibit bone healing: a review.

The ability of non-steroidal anti-inflammatory drugs (NSAID) to inhibit bone healing has been established in experimental animal models using mice, rats, and rabbits. The mechanism of action is largely unknown but stems from prostaglandin inhibition and is likely multifactorial. In human medicine NSAID are known to prevent heterotopic ossification, however the clinical importance of their effec...